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Bemnifosbuvir hemisulfate

CAS No. 2241337-84-6

Bemnifosbuvir hemisulfate( AT-527 )

Catalog No. M24018 CAS No. 2241337-84-6

Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Bemnifosbuvir hemisulfate
  • Note
    Research use only, not for human use.
  • Brief Description
    Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.
  • Description
    Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.
  • In Vitro
    Bemnifosbuvir hemisulfate has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively.In normal human airway epithelial cells, the concentration of Bemnifosbuvir hemisulfate required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells.
  • In Vivo
    When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir hemisulfate preferentially delivers high levels of AT-9010 in the liver in vivo.
  • Synonyms
    AT-527
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SARS-CoV-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2241337-84-6
  • Formula Weight
    1261.15
  • Molecular Formula
    C48H68F2N14O18P2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 170 mg/mL?(269.60mM;?Need ultrasonic)
  • SMILES
    C[C@@H](C(OC(C)C)=O)N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@H](N3C=NC4=C(NC)N=C(N)N=C34)[C@](C)(F)[C@@H]2O)=O.C[C@@H](C(OC(C)C)=O)N[P@@](OC5=CC=CC=C5)(OC[C@H]6O[C@@H](N7C=NC8=C(NC)N=C(N)N=C78)[C@](C)(F)[C@@H]6O)=O.O=S(O)(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Good S S , Westover J , Jung K H , et al. AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19[J]. Antimicrobial agents and chemotherapy, 65(4):e02479-20.
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